ChloroquineV1, Main, Exploration, bibRecord, 001904

A pre-emptive strike against malaria's stealthy hepatic forms

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A pre-emptive strike against malaria's stealthy hepatic forms

Auteurs : Dominique Mazier [France] ; Laurent Rénia [Singapour] ; Georges Snounou [France, Singapour]

Source :

Nature Reviews Drug Discovery [ 1474-1776 ] ; 2009-11.

RBID : ISTEX:7BE3547BB91B1E0076D61368580085B907EC8F5B

Abstract

Almost all the drugs that are widely used today against Plasmodium spp., the causative agent of malaria, target the asexual blood stages of the parasite. Widespread drug resistance severely restricts our ability to control malaria and makes it necessary to seek novel antimalarial compounds. Here, we advocate the development of true causal chemoprophylactic drugs that will fully inhibit the obligate short-lived hepatic forms that precede blood infections. Such drugs will prevent pathology and interrupt transmission, and could therefore have an important role in the control of malaria and its eventual eradication.

Url:

https://api.istex.fr/ark:/67375/GT4-3PBZVXZG-W/fulltext.pdf

DOI: 10.1038/nrd2960

Affiliations:

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to stream Istex, to step Curation: 001831
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Le document en format XML

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A pre-emptive strike against malaria's stealthy hepatic forms

A pre-emptive strike against malaria's stealthy hepatic forms

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Abstract

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